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KMID : 1161420100130041019
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Journal of Medicinal Food
2010 Volume.13 No. 4 p.1019 ~ p.1023
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Isolation and Anti-Inflammatory Activity of Bakuchiol from Ulmus davidiana var. japonica
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Choi Sang-Yoon
Lee Sang-Hyun
Choi Won-Hee
Lee Yeon-Mi
Jo Youn-Ock
Ha Tae-Youl
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Abstract
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The bark of the root and stem of Ulmus davidiana var. japonica has been used as a traditional Korean medicine to treat inflammatory disorders. This plant reportedly exhibits antioxidant, anticancer, and anti-inflammatory effects. A search for biologically active compounds in U. davidiana var. japonica extracts yielded bakuchiol, which we structurally identified on the basis of spectral data, including two-dimensional nuclear magnetic resonance spectroscopy and distortionless enhancement by polarization transfer. In our study, bakuchiol (50?μM) inhibited lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages by 53.7% and 84.2%, respectively. These results suggested that bakuchiol is one of the potent anti-inflammatory components of U. davidiana var. japonica.
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KEYWORD
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bakuchiol, nitric oxide, Ulmus davidiana var. japonica
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